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Sensitization to Aspergillus Mix Among Atopic Sickle Cell Disease Patients in Abidjan, Côte d’Ivoire

Received: 20 December 2020     Accepted: 28 December 2020     Published: 12 January 2021
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Abstract

The objective of this study was to determine the epidemiological characteristics of sensitization to Aspergillus in these atopic sickle cell patients who present respiratory disorders unrelated to taking NSAIDs. This is a prospective study with a descriptive and analytical aim which was conducted at the University Hospital Center (CHU) of Cocody (Abidjan). It took place from September 2017 to May 2018 on 117 atopic sickle cell disease patients, with no known history of allergy to aeroallergens, to any foods or to occupational allergens. These patients were interviewed and clinically examined for an atopic site. They were subsequently subjected to skin tests. Statistical analyzes were performed using Epi info 6.0 software using Fisher's test and odds ratio. The significance level was located at an odds ratio greater than 1. The comparison of the percentages was carried out by Fisher's test with a significance level p = 0.05. The majority of patients with sensitization to Aspergillus mix were over 15 years of age, with a predominance of women (Sex ratio: 0.56). Neither sex nor age appeared to influence the state of sensitization in our study (p> 0.05). The overall prevalence of sensitization to Aspergillus mix was 7.7%. Our results correlated asthma severity with sensitization to Aspergillus mix (p<0.05). However, there was no significant correlation between severity of allergic rhinitis and sensitization to Apergillus mix. This study confirms the low prevalence of sensitization to Aspergillus mix. Allergy to Aspergillus mix is an uncommon phenomenon in sickle cell patients but its monitoring in this population should be given special attention as it is subject to many complications.

Published in International Journal of Immunology (Volume 9, Issue 1)
DOI 10.11648/j.iji.20210901.11
Page(s) 1-5
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Sensitization, Aspergillus Mix, Atopic, Sickle Cell Disease

References
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Cite This Article
  • APA Style

    Adou Adjoumanvoule Honoré, Kabore Saydou, Dassé Sery Romuald, Yeboah Opong Richard, Goran-Kouacou Amah Patricia, et al. (2021). Sensitization to Aspergillus Mix Among Atopic Sickle Cell Disease Patients in Abidjan, Côte d’Ivoire. International Journal of Immunology, 9(1), 1-5. https://doi.org/10.11648/j.iji.20210901.11

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    ACS Style

    Adou Adjoumanvoule Honoré; Kabore Saydou; Dassé Sery Romuald; Yeboah Opong Richard; Goran-Kouacou Amah Patricia, et al. Sensitization to Aspergillus Mix Among Atopic Sickle Cell Disease Patients in Abidjan, Côte d’Ivoire. Int. J. Immunol. 2021, 9(1), 1-5. doi: 10.11648/j.iji.20210901.11

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    AMA Style

    Adou Adjoumanvoule Honoré, Kabore Saydou, Dassé Sery Romuald, Yeboah Opong Richard, Goran-Kouacou Amah Patricia, et al. Sensitization to Aspergillus Mix Among Atopic Sickle Cell Disease Patients in Abidjan, Côte d’Ivoire. Int J Immunol. 2021;9(1):1-5. doi: 10.11648/j.iji.20210901.11

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  • @article{10.11648/j.iji.20210901.11,
      author = {Adou Adjoumanvoule Honoré and Kabore Saydou and Dassé Sery Romuald and Yeboah Opong Richard and Goran-Kouacou Amah Patricia and Siransy Kouabla Liliane and N’Guessan Koffi and Assi Aya Ursule Aniela and Memel Lasme Roselle Charline and Zaho Ouleon Lea and Yassongui Mamadou Sekongo},
      title = {Sensitization to Aspergillus Mix Among Atopic Sickle Cell Disease Patients in Abidjan, Côte d’Ivoire},
      journal = {International Journal of Immunology},
      volume = {9},
      number = {1},
      pages = {1-5},
      doi = {10.11648/j.iji.20210901.11},
      url = {https://doi.org/10.11648/j.iji.20210901.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20210901.11},
      abstract = {The objective of this study was to determine the epidemiological characteristics of sensitization to Aspergillus in these atopic sickle cell patients who present respiratory disorders unrelated to taking NSAIDs. This is a prospective study with a descriptive and analytical aim which was conducted at the University Hospital Center (CHU) of Cocody (Abidjan). It took place from September 2017 to May 2018 on 117 atopic sickle cell disease patients, with no known history of allergy to aeroallergens, to any foods or to occupational allergens. These patients were interviewed and clinically examined for an atopic site. They were subsequently subjected to skin tests. Statistical analyzes were performed using Epi info 6.0 software using Fisher's test and odds ratio. The significance level was located at an odds ratio greater than 1. The comparison of the percentages was carried out by Fisher's test with a significance level p = 0.05. The majority of patients with sensitization to Aspergillus mix were over 15 years of age, with a predominance of women (Sex ratio: 0.56). Neither sex nor age appeared to influence the state of sensitization in our study (p> 0.05). The overall prevalence of sensitization to Aspergillus mix was 7.7%. Our results correlated asthma severity with sensitization to Aspergillus mix (p<0.05). However, there was no significant correlation between severity of allergic rhinitis and sensitization to Apergillus mix. This study confirms the low prevalence of sensitization to Aspergillus mix. Allergy to Aspergillus mix is an uncommon phenomenon in sickle cell patients but its monitoring in this population should be given special attention as it is subject to many complications.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Sensitization to Aspergillus Mix Among Atopic Sickle Cell Disease Patients in Abidjan, Côte d’Ivoire
    AU  - Adou Adjoumanvoule Honoré
    AU  - Kabore Saydou
    AU  - Dassé Sery Romuald
    AU  - Yeboah Opong Richard
    AU  - Goran-Kouacou Amah Patricia
    AU  - Siransy Kouabla Liliane
    AU  - N’Guessan Koffi
    AU  - Assi Aya Ursule Aniela
    AU  - Memel Lasme Roselle Charline
    AU  - Zaho Ouleon Lea
    AU  - Yassongui Mamadou Sekongo
    Y1  - 2021/01/12
    PY  - 2021
    N1  - https://doi.org/10.11648/j.iji.20210901.11
    DO  - 10.11648/j.iji.20210901.11
    T2  - International Journal of Immunology
    JF  - International Journal of Immunology
    JO  - International Journal of Immunology
    SP  - 1
    EP  - 5
    PB  - Science Publishing Group
    SN  - 2329-1753
    UR  - https://doi.org/10.11648/j.iji.20210901.11
    AB  - The objective of this study was to determine the epidemiological characteristics of sensitization to Aspergillus in these atopic sickle cell patients who present respiratory disorders unrelated to taking NSAIDs. This is a prospective study with a descriptive and analytical aim which was conducted at the University Hospital Center (CHU) of Cocody (Abidjan). It took place from September 2017 to May 2018 on 117 atopic sickle cell disease patients, with no known history of allergy to aeroallergens, to any foods or to occupational allergens. These patients were interviewed and clinically examined for an atopic site. They were subsequently subjected to skin tests. Statistical analyzes were performed using Epi info 6.0 software using Fisher's test and odds ratio. The significance level was located at an odds ratio greater than 1. The comparison of the percentages was carried out by Fisher's test with a significance level p = 0.05. The majority of patients with sensitization to Aspergillus mix were over 15 years of age, with a predominance of women (Sex ratio: 0.56). Neither sex nor age appeared to influence the state of sensitization in our study (p> 0.05). The overall prevalence of sensitization to Aspergillus mix was 7.7%. Our results correlated asthma severity with sensitization to Aspergillus mix (p<0.05). However, there was no significant correlation between severity of allergic rhinitis and sensitization to Apergillus mix. This study confirms the low prevalence of sensitization to Aspergillus mix. Allergy to Aspergillus mix is an uncommon phenomenon in sickle cell patients but its monitoring in this population should be given special attention as it is subject to many complications.
    VL  - 9
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Author Information
  • Immunology-Allergology Laboratory, UFR-SMA, University Félix Houphou?t-Boigny, Abidjan, Ivory Coast

  • Immunology-Allergology Laboratory, UFR-SMA, University Félix Houphou?t-Boigny, Abidjan, Ivory Coast

  • Immunology-Allergology Laboratory, UFR-SMA, University Félix Houphou?t-Boigny, Abidjan, Ivory Coast

  • Immunology-Allergology Laboratory, UFR-SMA, University Félix Houphou?t-Boigny, Abidjan, Ivory Coast

  • Immunology-Allergology Laboratory, UFR-SMA, University Félix Houphou?t-Boigny, Abidjan, Ivory Coast

  • Immunology-Allergology Laboratory, UFR-SMA, University Félix Houphou?t-Boigny, Abidjan, Ivory Coast

  • Immunology-Allergology Laboratory, UFR-SMA, University Félix Houphou?t-Boigny, Abidjan, Ivory Coast

  • Immunology-Allergology Laboratory, UFR-SMA, University Félix Houphou?t-Boigny, Abidjan, Ivory Coast

  • Immunology-Allergology Laboratory, UFR-SMA, University Félix Houphou?t-Boigny, Abidjan, Ivory Coast

  • Immunology-Allergology Laboratory, UFR-SMA, University Félix Houphou?t-Boigny, Abidjan, Ivory Coast

  • Immunology-Allergology Laboratory, UFR-SMA, University Félix Houphou?t-Boigny, Abidjan, Ivory Coast

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