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Effects of Sperm Treatment on the Anti-sperm Antibodies IgG and IgA

Received: 31 May 2017     Accepted: 12 June 2017     Published: 17 July 2017
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Abstract

Anti-sperm antibodies (ASA) form a class of glycoproteins commonly found in infertile men. This class of antibody causes an impairment of the spermatozoon's ability to cross cervical mucus and interact with the oocyte. The aim of our study was to analyze clinical and biological parameters of the sperm among positive ASA patients seen at the Center of Assisted Medical Procreation of the CHU Reunion before and after in-vitro treatment of autoimmune sperms. During the period from April 01, 2013 to February 29, 2015, we analyzed clinico-biological parameters of patients coming for exploring an infertility state with ASA IgG and IgA research before and after sperm treatment. Fourteen (1.51%) patients had a positive ASA, with a combination of ASA IgG and IgA for 71.42% of them. After in vitro treatment of the autoimmune sperm we found a persistence of IgA in 21.43% without IgG.

Published in International Journal of Immunology (Volume 5, Issue 3)
DOI 10.11648/j.iji.20170503.12
Page(s) 49-52
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Anti-Sperm Antibodies, Sperm Treatment, Réunion Island

References
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[3] Meinertz H, Linnet L, Fogh-Andersen P, et al. Antisperm anti-bodies and fertility after vasovasostomy: a follow-up study of216 men. FertilSteril 1990; 54: 315—21.
[4] World Health Organization. WHO Laboratory Manual for the Examination and Processing of Human Semen, 5th ed. Geneva 2010.
[5] Blanc B, Boubli L. Infertilité du couple. Gynécologie. Paris: ÉditionPradel; 2003.
[6] Merzndar S, Levine S. Antisperm antibodies: etiology, pathogenesis, diagnosis and treatment. FertilSteril 1998; 70: 799—810.
[7] Marconi M, Nowotny A, Pantke P. Antisperm antibodies detec-ted by mixed agglutination reaction and immunobead test arenot associated with chronic inflammation and infection of semi-nal tract. Andrology 2008; 40: 227—34.
[8] Wolff H, Polich JA, Martinez A, Haimovici F, Hill JA, AndersonDJ. Leukocytospermia is associated with poor semen quality. FertilSteril 1990; 53: 528—36.
[9] Lenzi, et al. Unilateral cryptorchidism corrected in prepubertalage: evaluation of sperm parameters, hormones and antispermantibodies in adult age. FertilSteril 1997; 5: 943—8.
[10] Gilbert BR, Witkim SS, Goldstein M. Correlation of sperm-boundimmunoglobulins with impaired semen analysis in infertile menwithvaricoceles. Fertil Steril 1989; 52: 469—73.
[11] Barthélémy C. Indications de la recherche des anticorps anti-spermatozoïdes. Andrologie 2003; 13(1): 70—80.
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[14] Meinertz H, Linnet L, Fogh-Andersen P, et al. Antisperm anti-bodies and fertility after vasovasostomy: a follow-up study of216 men. FertilSteril 1990; 54: 315—21.
[15] Check JH, Hourani W, Check ML, Graziano V, Levin E. Effectof treating antibody-coated sperm with chymotrypsin on pre-gnancy rates following IUI as compared to outcome of IVF/ICSI. ArchAndrol 2004; 50: 93—5.
[16] Ombelet W, Vandeput H, Janssen M, Cox A, Vossen C, PolletH, et al. Treatment of male infertility due to sperm surfaceantibodies: IUI or IVF? Hum Reprod 1997; 12(6): 1167—70.
[17] Naggy, et al. Results of 55 intracytoplasmic sperm injectioncycles in the treatment of male immunological infertility. HumReprod 1995; 10: 1775—80.
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[19] Francavilla F et al. (1992): Failure of intrauterine insemination in male immunological infertility in cases which all spermatozoa are antibody-coated. FertilSteril 58: 587–592.
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Cite This Article
  • APA Style

    Lheureux Helene, Randriamahazo Rakotomalala Toky, Mons Joffrey, Gabriele Marc. (2017). Effects of Sperm Treatment on the Anti-sperm Antibodies IgG and IgA. International Journal of Immunology, 5(3), 49-52. https://doi.org/10.11648/j.iji.20170503.12

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    ACS Style

    Lheureux Helene; Randriamahazo Rakotomalala Toky; Mons Joffrey; Gabriele Marc. Effects of Sperm Treatment on the Anti-sperm Antibodies IgG and IgA. Int. J. Immunol. 2017, 5(3), 49-52. doi: 10.11648/j.iji.20170503.12

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    AMA Style

    Lheureux Helene, Randriamahazo Rakotomalala Toky, Mons Joffrey, Gabriele Marc. Effects of Sperm Treatment on the Anti-sperm Antibodies IgG and IgA. Int J Immunol. 2017;5(3):49-52. doi: 10.11648/j.iji.20170503.12

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  • @article{10.11648/j.iji.20170503.12,
      author = {Lheureux Helene and Randriamahazo Rakotomalala Toky and Mons Joffrey and Gabriele Marc},
      title = {Effects of Sperm Treatment on the Anti-sperm Antibodies IgG and IgA},
      journal = {International Journal of Immunology},
      volume = {5},
      number = {3},
      pages = {49-52},
      doi = {10.11648/j.iji.20170503.12},
      url = {https://doi.org/10.11648/j.iji.20170503.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20170503.12},
      abstract = {Anti-sperm antibodies (ASA) form a class of glycoproteins commonly found in infertile men. This class of antibody causes an impairment of the spermatozoon's ability to cross cervical mucus and interact with the oocyte. The aim of our study was to analyze clinical and biological parameters of the sperm among positive ASA patients seen at the Center of Assisted Medical Procreation of the CHU Reunion before and after in-vitro treatment of autoimmune sperms. During the period from April 01, 2013 to February 29, 2015, we analyzed clinico-biological parameters of patients coming for exploring an infertility state with ASA IgG and IgA research before and after sperm treatment. Fourteen (1.51%) patients had a positive ASA, with a combination of ASA IgG and IgA for 71.42% of them. After in vitro treatment of the autoimmune sperm we found a persistence of IgA in 21.43% without IgG.},
     year = {2017}
    }
    

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    T1  - Effects of Sperm Treatment on the Anti-sperm Antibodies IgG and IgA
    AU  - Lheureux Helene
    AU  - Randriamahazo Rakotomalala Toky
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    N1  - https://doi.org/10.11648/j.iji.20170503.12
    DO  - 10.11648/j.iji.20170503.12
    T2  - International Journal of Immunology
    JF  - International Journal of Immunology
    JO  - International Journal of Immunology
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    SN  - 2329-1753
    UR  - https://doi.org/10.11648/j.iji.20170503.12
    AB  - Anti-sperm antibodies (ASA) form a class of glycoproteins commonly found in infertile men. This class of antibody causes an impairment of the spermatozoon's ability to cross cervical mucus and interact with the oocyte. The aim of our study was to analyze clinical and biological parameters of the sperm among positive ASA patients seen at the Center of Assisted Medical Procreation of the CHU Reunion before and after in-vitro treatment of autoimmune sperms. During the period from April 01, 2013 to February 29, 2015, we analyzed clinico-biological parameters of patients coming for exploring an infertility state with ASA IgG and IgA research before and after sperm treatment. Fourteen (1.51%) patients had a positive ASA, with a combination of ASA IgG and IgA for 71.42% of them. After in vitro treatment of the autoimmune sperm we found a persistence of IgA in 21.43% without IgG.
    VL  - 5
    IS  - 3
    ER  - 

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Author Information
  • Assisted Medical Procreation Center, University Center Hospital South Réunion, Réunion Island, France

  • Assisted Medical Procreation Center, University Center Hospital South Réunion, Réunion Island, France

  • Assisted Medical Procreation Center, University Center Hospital South Réunion, Réunion Island, France

  • Assisted Medical Procreation Center, University Center Hospital South Réunion, Réunion Island, France

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