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Intensive Phase of Therapy of Tuberculosis and HIV Co-infection: CD4, CD8, and Certain Hematological Finding Amongst Patients in Yaounde Cameroon

Received: 13 November 2015     Accepted: 24 November 2015     Published: 14 December 2015
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Abstract

Tuberculosis (TB) is an infectious disease which could cause depressive phenomena like those observed in Human Immunodeficiency Virus (HIV). Our study aimed at evaluating the changes of T-cells and certain blood parameters during intensive phase of TB treatment. In this prospective cohort, 140 consenting tuberculosis patients were enrolled. 5ml of blood was collected at baseline (M0), after one month (M1) and after two months (M2). Enumeration of CD4 cells, CD8 cells, and hematological parameters were done following standard protocols.The 118 participants comprised 63 (53.4%) TB/HIV negative patients (group 1) and 55 (46.6%) TB/HIV positive patients (group 2). At M0, blood levels of CD4, hemoglobin, total lymphocytes and platelets in group 2 were significantly lower than those of group 1 with p values of 0.001, 0.002, 0.018 and 0.032 respectively. CD8 level was significantly low in group 1 as compared to group 2 (p value: 0.38). Monocytes were low in both groups with no significant difference (p value: 0.097). At M2, there was a significant increase in the levels of CD4, CD8, monocytes, and hemoglobin as compared to M0. There was no significant change on level of total lymphocytes and platelets. In group 2: At M2, there was a significant increase in the levels of CD4, monocytes, hemoglobin, and platelets, and no statistically significant change on levels of CD8 cells and total lymphocytes. TB infection may result in lymphopenia, monopenia, and anemia, while co-infection with HIV may add thrombopenia to the mentioned disorders.

Published in International Journal of Immunology (Volume 3, Issue 6)
DOI 10.11648/j.iji.20150306.12
Page(s) 72-77
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Anemia, HIV, Lymphopenia, Monopenia, Thrombopenia, Treatment, Tuberculosis

References
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Cite This Article
  • APA Style

    Guiedem Elise, Pefura Yone Eric Walter, Ikomey George, Gonsu Kamga Hortense, Monamele Chavely Gwladys, et al. (2015). Intensive Phase of Therapy of Tuberculosis and HIV Co-infection: CD4, CD8, and Certain Hematological Finding Amongst Patients in Yaounde Cameroon. International Journal of Immunology, 3(6), 72-77. https://doi.org/10.11648/j.iji.20150306.12

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    ACS Style

    Guiedem Elise; Pefura Yone Eric Walter; Ikomey George; Gonsu Kamga Hortense; Monamele Chavely Gwladys, et al. Intensive Phase of Therapy of Tuberculosis and HIV Co-infection: CD4, CD8, and Certain Hematological Finding Amongst Patients in Yaounde Cameroon. Int. J. Immunol. 2015, 3(6), 72-77. doi: 10.11648/j.iji.20150306.12

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    AMA Style

    Guiedem Elise, Pefura Yone Eric Walter, Ikomey George, Gonsu Kamga Hortense, Monamele Chavely Gwladys, et al. Intensive Phase of Therapy of Tuberculosis and HIV Co-infection: CD4, CD8, and Certain Hematological Finding Amongst Patients in Yaounde Cameroon. Int J Immunol. 2015;3(6):72-77. doi: 10.11648/j.iji.20150306.12

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  • @article{10.11648/j.iji.20150306.12,
      author = {Guiedem Elise and Pefura Yone Eric Walter and Ikomey George and Gonsu Kamga Hortense and Monamele Chavely Gwladys and Fokam Joseph and Mesembe Martha and Afane Ze Emmanuel and Okomo Assoumou Marie Claire},
      title = {Intensive Phase of Therapy of Tuberculosis and HIV Co-infection: CD4, CD8, and Certain Hematological Finding Amongst Patients in Yaounde Cameroon},
      journal = {International Journal of Immunology},
      volume = {3},
      number = {6},
      pages = {72-77},
      doi = {10.11648/j.iji.20150306.12},
      url = {https://doi.org/10.11648/j.iji.20150306.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20150306.12},
      abstract = {Tuberculosis (TB) is an infectious disease which could cause depressive phenomena like those observed in Human Immunodeficiency Virus (HIV). Our study aimed at evaluating the changes of T-cells and certain blood parameters during intensive phase of TB treatment. In this prospective cohort, 140 consenting tuberculosis patients were enrolled. 5ml of blood was collected at baseline (M0), after one month (M1) and after two months (M2). Enumeration of CD4 cells, CD8 cells, and hematological parameters were done following standard protocols.The 118 participants comprised 63 (53.4%) TB/HIV negative patients (group 1) and 55 (46.6%) TB/HIV positive patients (group 2). At M0, blood levels of CD4, hemoglobin, total lymphocytes and platelets in group 2 were significantly lower than those of group 1 with p values of 0.001, 0.002, 0.018 and 0.032 respectively. CD8 level was significantly low in group 1 as compared to group 2 (p value: 0.38). Monocytes were low in both groups with no significant difference (p value: 0.097). At M2, there was a significant increase in the levels of CD4, CD8, monocytes, and hemoglobin as compared to M0. There was no significant change on level of total lymphocytes and platelets. In group 2: At M2, there was a significant increase in the levels of CD4, monocytes, hemoglobin, and platelets, and no statistically significant change on levels of CD8 cells and total lymphocytes. TB infection may result in lymphopenia, monopenia, and anemia, while co-infection with HIV may add thrombopenia to the mentioned disorders.},
     year = {2015}
    }
    

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    T1  - Intensive Phase of Therapy of Tuberculosis and HIV Co-infection: CD4, CD8, and Certain Hematological Finding Amongst Patients in Yaounde Cameroon
    AU  - Guiedem Elise
    AU  - Pefura Yone Eric Walter
    AU  - Ikomey George
    AU  - Gonsu Kamga Hortense
    AU  - Monamele Chavely Gwladys
    AU  - Fokam Joseph
    AU  - Mesembe Martha
    AU  - Afane Ze Emmanuel
    AU  - Okomo Assoumou Marie Claire
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    JF  - International Journal of Immunology
    JO  - International Journal of Immunology
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    PB  - Science Publishing Group
    SN  - 2329-1753
    UR  - https://doi.org/10.11648/j.iji.20150306.12
    AB  - Tuberculosis (TB) is an infectious disease which could cause depressive phenomena like those observed in Human Immunodeficiency Virus (HIV). Our study aimed at evaluating the changes of T-cells and certain blood parameters during intensive phase of TB treatment. In this prospective cohort, 140 consenting tuberculosis patients were enrolled. 5ml of blood was collected at baseline (M0), after one month (M1) and after two months (M2). Enumeration of CD4 cells, CD8 cells, and hematological parameters were done following standard protocols.The 118 participants comprised 63 (53.4%) TB/HIV negative patients (group 1) and 55 (46.6%) TB/HIV positive patients (group 2). At M0, blood levels of CD4, hemoglobin, total lymphocytes and platelets in group 2 were significantly lower than those of group 1 with p values of 0.001, 0.002, 0.018 and 0.032 respectively. CD8 level was significantly low in group 1 as compared to group 2 (p value: 0.38). Monocytes were low in both groups with no significant difference (p value: 0.097). At M2, there was a significant increase in the levels of CD4, CD8, monocytes, and hemoglobin as compared to M0. There was no significant change on level of total lymphocytes and platelets. In group 2: At M2, there was a significant increase in the levels of CD4, monocytes, hemoglobin, and platelets, and no statistically significant change on levels of CD8 cells and total lymphocytes. TB infection may result in lymphopenia, monopenia, and anemia, while co-infection with HIV may add thrombopenia to the mentioned disorders.
    VL  - 3
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Author Information
  • Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon

  • Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon

  • Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon

  • Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon

  • Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon

  • Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon

  • Center for the Study and Control of Communicable Diseases (CSCCD), Yaounde, Cameroon

  • Pneumological Service, Yaounde Jamot Hospital, Yaounde, Cameroon

  • Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon

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