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Subcutaneous versus Sublingual Immunotherapy for Allergic Rhinitis therapy: Which Is Superior

Received: 8 June 2015     Accepted: 18 June 2015     Published: 2 July 2015
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Abstract

Background: A randomized single-blinded study including 50 patients with allergic rhinitis. Objective: To evaluate and compare the efficacy of subcutaneous versus sublingual immunotherapy in treatment of allergic rhinitis. Materials and methods: Patients divided into Group A: twenty patients received subcutaneous immunotherapy and group B: twenty patients received sublingual immunotherapy for twelve months. We assessed skin prick test, symptom score and medication use, quality of life and nasal smear eosinophilic count before and after treatment. Results: In group A, clinical improvement was achieved in 100% of monosensitised and 62.5% of polysensitised patients, while in group B 100% of monosensitised and 60% of of polysensitised patients exhibited clinical improvement. Conclusion: The subcutaneous and sublingual routes of immunotherapy have similar efficacy.

Published in International Journal of Immunology (Volume 3, Issue 3)
DOI 10.11648/j.iji.20150303.13
Page(s) 42-46
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Allergen Specific Immunotherapy, SCIT, SLIT, Allergic Rhinitis, Skin Prick Test, Nasal Smear Eosinophilia, Clinical Improvement

References
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Cite This Article
  • APA Style

    Magdy Abdullah Sayedelahl, Naser Nagib Nasr, Mahmoud Hamed Akr, Dina Sayed Sheha, Tahany Mohamed Rabie. (2015). Subcutaneous versus Sublingual Immunotherapy for Allergic Rhinitis therapy: Which Is Superior. International Journal of Immunology, 3(3), 42-46. https://doi.org/10.11648/j.iji.20150303.13

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    ACS Style

    Magdy Abdullah Sayedelahl; Naser Nagib Nasr; Mahmoud Hamed Akr; Dina Sayed Sheha; Tahany Mohamed Rabie. Subcutaneous versus Sublingual Immunotherapy for Allergic Rhinitis therapy: Which Is Superior. Int. J. Immunol. 2015, 3(3), 42-46. doi: 10.11648/j.iji.20150303.13

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    AMA Style

    Magdy Abdullah Sayedelahl, Naser Nagib Nasr, Mahmoud Hamed Akr, Dina Sayed Sheha, Tahany Mohamed Rabie. Subcutaneous versus Sublingual Immunotherapy for Allergic Rhinitis therapy: Which Is Superior. Int J Immunol. 2015;3(3):42-46. doi: 10.11648/j.iji.20150303.13

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  • @article{10.11648/j.iji.20150303.13,
      author = {Magdy Abdullah Sayedelahl and Naser Nagib Nasr and Mahmoud Hamed Akr and Dina Sayed Sheha and Tahany Mohamed Rabie},
      title = {Subcutaneous versus Sublingual Immunotherapy for Allergic Rhinitis therapy: Which Is Superior},
      journal = {International Journal of Immunology},
      volume = {3},
      number = {3},
      pages = {42-46},
      doi = {10.11648/j.iji.20150303.13},
      url = {https://doi.org/10.11648/j.iji.20150303.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20150303.13},
      abstract = {Background: A randomized single-blinded study including 50 patients with allergic rhinitis. Objective: To evaluate and compare the efficacy of subcutaneous versus sublingual immunotherapy in treatment of allergic rhinitis. Materials and methods: Patients divided into Group A: twenty patients received subcutaneous immunotherapy and group B: twenty patients received sublingual immunotherapy for twelve months. We assessed skin prick test, symptom score and medication use, quality of life and nasal smear eosinophilic count before and after treatment. Results: In group A, clinical improvement was achieved in 100% of monosensitised and 62.5% of polysensitised patients, while in group B 100% of monosensitised and 60% of of polysensitised patients exhibited clinical improvement. Conclusion: The subcutaneous and sublingual routes of immunotherapy have similar efficacy.},
     year = {2015}
    }
    

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    T1  - Subcutaneous versus Sublingual Immunotherapy for Allergic Rhinitis therapy: Which Is Superior
    AU  - Magdy Abdullah Sayedelahl
    AU  - Naser Nagib Nasr
    AU  - Mahmoud Hamed Akr
    AU  - Dina Sayed Sheha
    AU  - Tahany Mohamed Rabie
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    PY  - 2015
    N1  - https://doi.org/10.11648/j.iji.20150303.13
    DO  - 10.11648/j.iji.20150303.13
    T2  - International Journal of Immunology
    JF  - International Journal of Immunology
    JO  - International Journal of Immunology
    SP  - 42
    EP  - 46
    PB  - Science Publishing Group
    SN  - 2329-1753
    UR  - https://doi.org/10.11648/j.iji.20150303.13
    AB  - Background: A randomized single-blinded study including 50 patients with allergic rhinitis. Objective: To evaluate and compare the efficacy of subcutaneous versus sublingual immunotherapy in treatment of allergic rhinitis. Materials and methods: Patients divided into Group A: twenty patients received subcutaneous immunotherapy and group B: twenty patients received sublingual immunotherapy for twelve months. We assessed skin prick test, symptom score and medication use, quality of life and nasal smear eosinophilic count before and after treatment. Results: In group A, clinical improvement was achieved in 100% of monosensitised and 62.5% of polysensitised patients, while in group B 100% of monosensitised and 60% of of polysensitised patients exhibited clinical improvement. Conclusion: The subcutaneous and sublingual routes of immunotherapy have similar efficacy.
    VL  - 3
    IS  - 3
    ER  - 

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Author Information
  • Department of Otorhinolaryngology, Faculty of Medicine, Zagazig University, Zagazig, Egypt

  • Department of Otorhinolaryngology, Faculty of Medicine, Zagazig University, Zagazig, Egypt

  • Department of Otorhinolaryngology, Faculty of Medicine, Zagazig University, Zagazig, Egypt

  • Department of Internal Medicine, Allergy and Clinical Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

  • Department of Otorhinolaryngology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

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